Start hereSafety 1 min read
Is this right for me? A screening primer
The health history, medications, and life circumstances that make psychedelic sessions unsafe or ill-timed.
PsiloAtlas editorial · AI-assisted information, not clinical review · Reviewed 2026-07-01
Common medical exclusions
Reputable providers screen carefully, and a provider who doesn't screen is not a reputable provider. Screening is not a formality, it exists because a small number of people face materially higher risk.
- Personal or first-degree family history of schizophrenia or bipolar I disorder
- Uncontrolled hypertension or significant cardiac conditions
- Pregnancy or breastfeeding
- Recent suicide attempt or active acute crisis
Medications worth flagging
Bring a complete medication list, including supplements, to any consultation. Lithium combined with psilocybin has been associated with seizures. SSRIs and SNRIs can blunt or complicate effects. MAOIs interact dangerously with MDMA.
Never taper a psychiatric medication on your own to prepare for a session. Any change belongs with your prescriber.
Questions to ask yourself
Do you have support for the days afterward? Can you take time off? Are you doing this out of curiosity, out of desperation, or as part of a considered plan of care? None of those answers disqualify you, but they change how you should prepare.