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Legal status
South Carolina
No legal psilocybin accessFAQ →Bill tracker →Español →Providers and retreats in South Carolina →Reviewed October 2026
What psychedelic access is allowed in South Carolina?
No legal psilocybin access. Access depends on the substance and setting; this is not blanket permission to possess, buy or sell psychedelics.
Official source: South Carolina, official statutes and legislature →Psilocybin is a Schedule I controlled substance under South Carolina law. Possession, sale and facilitation are criminal offenses; clinical trials are the only lawful route.
Current law
South Carolina controlled substances law
- Possession or sharing psilocybin can be prosecuted
- Clinical trials are the only lawful route
- Ketamine can be prescribed off-label by licensed clinicians
Providers and their documented services
3 listedCharleston Ketamine Center — Columbia
Columbia, SC
Listed, not verified
Charleston Ketamine Center — Columbia
Columbia, SC
Documented services
Ketamine therapy
Sources
- Organization's own informationSource checked 2026-11-08Charleston Ketamine Center — Columbia: Official services and clinic information
Charleston Ketamine Center — Mount Pleasant
Mount Pleasant, SC
Listed, not verified
Charleston Ketamine Center — Mount Pleasant
Mount Pleasant, SC
Documented services
Ketamine therapy
Sources
- Organization's own informationSource checked 2026-11-08Charleston Ketamine Center — Mount Pleasant: Official services and clinic information
MUSC Health Centerspace Clinic
Charleston, SC
Listed, not verified
MUSC Health Centerspace Clinic
Charleston, SC
Documented services
Ketamine-rooted therapy
Sources
- Organization's own informationSource checked 2026-11-08MUSC Health Centerspace Clinic: Official services and clinic information