How much does ketamine therapy cost?

No government agency publishes ketamine clinic prices, so the most reliable numbers are the ones clinics post themselves. Four Colorado clinics we checked list $250 to $450 per mental-health infusion or treatment (table below). Several also charge a separate first assessment.

Infusions for chronic pain usually cost more because they run longer: Summit Ketamine Innovations lists $1,350 per pain or migraine infusion.

Clinics usually start with a series of treatments over a few weeks. Vitalitas says a typical initial series is six infusions; Summit says people with treatment-resistant depression generally receive 8 to 12 treatments over 8 weeks, then occasional boosters. At the prices above, a first series is roughly $1,500 to $5,400 before any intake fees, and boosters add to that if you continue.

Usually not. Ketamine is not FDA-approved for depression or other psychiatric conditions, so infusions are typically self-pay. Some clinics provide paperwork for out-of-network reimbursement or HSA/FSA use.

Spravato (esketamine nasal spray) is different: it is FDA-approved for treatment-resistant depression and for depressive symptoms with acute suicidal thoughts, so many insurers cover it after prior authorization.

Spravato can only be given in a certified clinic, where staff must watch you for at least two hours after each dose. Your bill often has separate parts: the drug, the in-office visit and observation, and sometimes a facility fee. Ask the clinic to check your benefits and give you a written estimate for each part before the first session.

The manufacturer runs savings and patient-assistance programs; eligibility depends on your insurance and income, so ask the clinic for details.

Ask what the price includes (assessment, monitoring, follow-up visits), whether package prices are refundable, who monitors you during treatment, and what happens if you are found ineligible after paying. Our printable list of questions covers the rest.